apalutamide will minimize the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medications which have been CYP2C19 substrates may lead to lower publicity to these remedies.crizotinib increases amounts of diazepam by aff